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The structure was then refined in an iterative procedure via refinement using the software Refmac 5.02 [22] and manually rebuilding using Quanta2006 (Accelrys).
The selected model was then refined by loop modeling and side chain refinement to increase the Profile3D score and to make the model reliable [ 28].
The structure of the binary complex GDF-5 R57A BMPR-IA was then refined by iterative cycles of manual rebuilding using Quanta2008 and refinement using Refmac version 5.02 of the software package CCP4.
This approximate age was then refined using radioactive isotopes.
The shifted model was then refined with half1 map in Phenix.
The representation of the Ecobordure triangle was then refined through segmentation in seven sectors to facilitate the reading and interpretation of results.
Existing frameworks are compared in order to develop a draft framework, which was then refined through consultation with water industry experts.
It was then refined by the image matchers developed based on Adaptive Least Squared Correlation (ALSC) algorithms (Gruen, 1985) which possess sub-pixel matching capability.
The set of CANs was then refined to incorporate these rules using a method of multiple criterion synchronization discussed in the next section.
It was then refined with a subject-specific strategy to identify studies addressing the shoulder and its natural history, non-operative therapy and its relationship to regression to the mean (Fig. 1).
The structure was determined by molecular replacement using MRG2CD (PDB: 4PLI) as a search model (Bu et al., 2014), and the structure was then refined via Phenix (Adams et al., 2010) (Table 1).
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