This scepticism is supported by database investigations showing that retention of the wild-type allele occurs with the same frequency as either nonsense or missense TP53 mutations.
This work was supported by the Database Integration Coordination Program of the National Bioscience Database Center JSPS KAKENHII Grant Numbers 15H05897, 15H05898, 15H04648, 15K01812; Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry; and the JST-Core Research for Evolutionary Science and Technology (JST-CREST).
The primary breast material collection was supported by the Database and Tissue Bank Axis of the Réseau de recherche en cancer of the Fonds de recherche du Québec-Santé (FRQS).
Neurotoxicity was supported by a considerable database of human, animal, and mechanistic studies.
Data interpretation was supported by the Griss proteomics database engine (GPDE) [ 70, 71].
For comparative analyses, which was supported by our specially designed database, the GPDE (see Methods), the proteome profile of skin fibroblasts, comprising 1496 proteins (Additional file 4: Table S3), as well as that of BM-derived fibroblasts, including 1569 proteins (Additional file 5: Table S4) were further used.
The physical protein-protein interaction scores ranged from 0 to 5; 0 meant that the interaction was from none of these databases, while 5 meant that the interaction was supported by each of these databases.
Recruiting of patients was supported by use of patient databases; the German network for mitochondrial disorders (mitoNET, 01GM0862), which is funded by the German Ministry of Education and Research BMBFF, Bonn, Germany), and the UK Mitochondrial Disease Cohort, which is funded by the Medical Research Council (UK).
Development of the Reactome database was supported by grants from the National Human Genome Research Institute at the National Institutes of Health (grant number P41 HG003751); the European Union 6th Framework Programme 'ENFIN' (grant number LSHG-CT-2005-518254). Funding for open access charge: National Institutes of Health grant number P41 HG003751.
Phylogenetic analysis was supported as part of The Center for LignoCellulose Structure and Formation, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award # DE-SC0001090 (TWM and CTA), and development of the PlantTribes 2.0 database was supported by NSF Plant Genome grant #0922742 (JPD, LAH, and CWD).
This was supported by analysis of the mouse knockout database, which showed that a wide range of phenotypes and diseases resulted from knock out of genes in the pleiotropic module (Bonferroni corrected P-values from P < 10-50, FETableble S15 in Additional file 1).
