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In addition, another conserved residue, tryptophan-398 was suggested to function in PHA synthase subunit dimerization by the provision of a hydrophobic surface (Gerngross et al., [1994]; Jia et al., [2001]).
C. elegans TRPA-1, the ortholog of the mammalian TRPA1, was suggested to function in mechanosensation [29].
ERL1 was suggested to function in proliferating cells, such as leaf primordial cells, and correspondingly, ERL1 GUS was strongly upregulated in the upper part of hypocotyl in AP2C3oe plants.
In addition, JMJD3 was suggested to function in the neural stem cell differentiation [ 23].
Consequently, CAND1 was suggested to function as a global regulator of cullin-containing ubiquitin ligases [ 81, 83].
Osteocalcin was suggested to function as a hormone in energy metabolism, regulating insulin sensitivity through an effect on adiponectin (4).
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A strictly conserved glutamate residue is suggested to function catalytically in thioester proteins.
AQP1 has been suggested to function as an ion channel upon cGMP activation, although this idea has been controversial.
Chromatoid bodies (CBs) are characteristic spermatid organelles, which were suggested to function in RNA storage and small RNA processing but whose functions remain largely unknown.
For example, cell cycle, DNA methylation, and tumor progresses have been suggested to function together under certain circumstances (Robertson et al., 2000; Wu et al., 1993).
Consequently, a number of nucleases have been suggested to function in ICL repair, including MUS81-EME1, XPF-ERCC1 and SLX4-SLX1 (Douwet et al., 2014).
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