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Finally, the CONSORT criteria was suggested primarily for randomized controlled trials, which in this particular case only accounted for about 10% of the study designs in conference abstracts.
A further theory, termed the odontoblast transducer mechanism by Rapp et al. [ 21], was suggested primarily because odontoblasts are embryologically of neural crest derived mesenchymal cells.
Again, when cross-classifying patients by Recurrence Score and tumor size and grade, an improvement in risk prediction was suggested primarily for those with Recurrence Score values categorized as low risk.
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In addition, the CONSORT criteria were suggested primarily for randomized-controlled trials which took only about 2-72-7% studesignsgns in conference abstracts.
When first described, IFNλ was suggested to primarily act on cells of epithelial origin [ 3], making it an activator of the innate immune response.
Although this was suggested to occur primarily by regulatory mutations that partition expression of the genes spatially, other forms of subfunctionalization could also occur.
In earlier work [ 8] it was suggested that amorphogenesis primarily resulted from substrate changes such as cellulose delamination or fibrillation, where relatively large, intact fragments, still containing crystalline regions, are released from the bulk of the substrate.
It was suggested that HQ is primarily exuded to acquire Fe for the donor plant, and the reduced phytotoxicity of HQ was argued due to the binary mixture of HQ and metal ions.
FTO was first identified as a type 2 diabetes-susceptibility gene, but, as further adjustment for BMI abolished the association with type 2 diabetes [ 1], it was suggested that FTO is primarily an obesity-susceptibility locus.
A lack of correlation between inhibitor potency and parasite killing was also reported by Lemercier et al. for a series of imidazopyridazine inhibitors of PfCDPK1 and was suggested to be a limitation, primarily of poor inhibitor membrane permeability (16).
The S/MARs have been suggested to primarily localize near the transcription start sites [ 74, 75] or correlate with the origins of DNA replication [ 76].
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