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In the last quarter, it reported a loss of $41.4 million, in part because its coal production was substantially down as a result of increased regulatory oversight of its operations.
Fig. 3d shows the tPA level was substantially down regulated by transfecting astrocytes with tPA siRNA.
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Moreover, JNK phosphorylation was substantially down-regulated in liver lysates of HS+MES-treated mice (Fig. 4C; pJNK).
The potential clinical significance of the NKp30 down-regulation is highlighted by its importance in recognizing melanoma cells, as suggested by the results described in Figure 5. On the other hand, CD16 was substantially down-regulated in melanoma patients (Figure 6) and did not directly bind to melanoma cells (Figure 5).
Only one of two B-type response regulator genes was substantially down-regulated upon callus induction.
For the pair OsATG13a and OsATG13b, OsATG13b was substantially down-regulated after various stress treatments, but OsATG13a was slightly up-expressed by abiotic stresses (Fig. 5K).
PRDM5 protein expression was substantially down-regulated in both BRAF mutant and wild type cancer cohorts (92/97,95% and 39/44,89%).
A putative ortholog to cyp6g1 was substantially down-regulated in NWS resistant individuals and this is the first report of down-regulation of this CYP gene possibly associated with insecticide resistance.
Milk is substantially down in price".
Sky's audience was always going to be substantially down on last year's free-to-air coverage.
Box office has been substantially down on last year's equivalent numbers for all four weekends in March so far.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com