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Passenger traffic was substantial, rising from 11,500 passengers carried in 1867 to over 23,000 (roughly equivalent to 40,000 passenger journeys) in 1877.
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The inflation of the incidence estimate related to false-recent results for long-term infected subjects can be substantial, rises with increased prevalence in the test population, and has been noted before [17] [19], [21], [27] [29].
The isolated pathogens were the same: Acinetobacter spp. (19%), Serratia spp. (16%), but there was substantial rise in emergence of S. epidermidis during the last year.
In early experimental neuromas, there are substantial rises in local blood flow associated with their formation, but human studies of chronic lesions have suggested that neuromas develop ischemia and become impediments to regeneration.
Given its chronic progressive nature, the rise in prevalence with age and the increasing longevity of the population, the impact of the disease is substantial and rising.
A Belgian study 2 indicates that few currently authorised orphan drugs meet a €34 000 (£27 900; $43 000) per QALY (quality adjusted life year) cost effectiveness threshold and that the budget impact of orphan drugs is substantial and rising.
The stems themselves are green, and the thorns are substantial, resembling rose thorns.
By contrast, the rise in the basic per-ride fare in 2003, from $1.50 to $2, was substantial.
"It was substantial".
was substantial & immediate.
The hype was substantial.
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CEO of Professional Science Editing for Scientists @ prosciediting.com