Interventional procedures included all image-guided procedures (such as angiography, bronchography, myelography, percutaneous transhepatic cholangiography, endoscopic retrograde cholangiopancreatography, biopsy, drainage, aspiration, etc).. Procedures in which radiation was specifically delivered for therapeutic purposes, such as high-dose radiation therapy for cancers, were excluded.
Fluorescence intensity was significantly stronger at tumor mass of MDA-MB231 cells than solid mass of NIH3T3 cells, indicating that HAssLG nanoparticles were specifically delivered to tumor cells.
Our immunohistochemical results showed that a large number of CD44 receptors were expressed on the 4T1 cell membrane, while few were observed in the cytoplasm, indicating that CD44-PEG-GNCs can be specifically delivered to 4T1 cells.
This property potentially makes them highly selective for killing targeted single cancer cells, provided that they can be specifically delivered to tumor cells, internalized, and transported to the cell nucleus [3].
Second, the tRNAs could be specifically delivered by the eEF1A/Nef/tRNA complexes to cytosolic cytochrome c, thereby preventing cytochrome c interaction with Apaf-1 and blocking caspase activation and apoptosis.
Moreover, SST analogs labeled with therapeutic radionuclides can be specifically delivered to transfected tumors, which provides an alternative approach to conventional therapeutics for SSTR negative or weakly positive tumors [ 102].
We have previously shown that PEGylated QDs functionalized with a polyarginine 'Tat-like' CPP (cell-penetrating peptide) can be specifically delivered to cells via endocytic uptake with no adverse effects on cellular proliferation (Delehanty et al., 2006), but remain sequestered within acidic endolysosomal vesicles for at least 3 days after initial uptake (Delehanty et al., 2010).
After intravenous injection, CSLN/siCTGF complex was target specifically delivered to the liver and resulted in a significant reduction in collagen content and pro-fibrogenic factors like tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), interleukin-6 (IL-6), and CTGF with the dramatic improvement of patho-physiological symptoms in liver fibrosis model rats.
Mechanical ventilation was provided using an Osiris ventilator (Taema, Antony, France), which was specifically designed for delivering 100% oxygen during transportation of critically ill patients.
Trump blasted the format of Monday night's debate by claiming that the presence of Clinton was "specifically designed" to distract him from delivering his message to the American people.
Accordingly, the antisense MIF/SPG complex is effectively and specifically delivered to macrophages and dendritic cells expressing Dectin-1 on their membranous surface.
