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The Calcium signaling pathway was specifically altered by the down-regulated genes, whereas the Wnt signaling pathway was specifically altered by the up-regulated genes.
Moreover, the quantity of paxillin in talin-containing complexes was specifically altered under LRP-1 silencing whereas the α-actinin was not.
We found that the retrograde signaling pathway triggered by O2 was specifically altered in the alloplasmic line carrying the H. chilense cytoplasm.
To study whether autophagy was specifically altered in the CNS of tgMT mice, we examined microtubule-associated protein 1 LC3, an established autophagy marker, by immunostaining and immunoblots.
These co-localisation studies confirm that Rrm4 movement was specifically altered in the absence of Upa1 and that residual processive movement took place on endosomes.
GO analysis of the 68 transcripts whose expression was specifically altered in bacteria-injected workers (corresponding to 50 unique Flybase genes) yielded only one significantly overrepresented cluster (immune response; p=0.001).
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However, some common regions displayed higher frequency and/or higher amplitude of alteration in IBCs, and other regions were specifically altered in IBCs such as 5p15.33, previously associated with poor prognosis in breast [61] and bladder cancers [62].
Plant responses to wounding/insect feeding are known to be specifically altered by the plant's perception of herbivore-specific elicitors [ 8, 39- 42].
For aiding cancer diagnosis, a biomarker should be specifically altered in the majority of patients with a specific malignancy or premalignant condition.
In particular, our study has identified specific regions, whose coordinated maturation with the rest of the brain may be specifically altered in schizophrenia, contributing to greater severity.
Gene targeting in embryonic stem cells allows endogenous genes to be specifically altered.
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