As an example, compound 2 (a non-TA compound) was shown to bind at the TA binding site.
Thus, as with the SPR-derived binding results, WW2 was shown to bind with highest affinity, closely followed by WW3.
MUC4 was shown to bind and sterically hinder HER2 from binding to trastuzumab [ 26, 27].
SHP-1 was shown to bind to this ITIM in synthetic peptide binding experiment.
This soluble INSR was shown to bind INS (Papa et al, 1993); its IGF binding has not yet been investigated.
Vps1 was shown to bind actin and the vps1 RR-EE mutation reduced actin binding as predicted.
Recently, the periplasmic chaperone-like protein CsgC was shown to bind directly to CsgA in vitro and prevent premature aggregation14.
Previously, Ies2 was shown to bind to the ATPase domain of Ino80, consistent with our DNA crosslinking data for Ies219.
Based on structural and biochemical analysis, the bipartite SEC14-PH domain was shown to bind to phospholipids [42, 43].
This hemodextrin ensemble was shown to bind dioxygen reversibly and to form a stable ferryl species.
TFIID was shown to bind promoter DNA in a reorganized state.
