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The silent C3435T polymorphism (rs1045642) in exon 26 of ABCB1 was the first polymorphism to be described; it was reported to modify P-gp expression [ 15] (Table 1).
A decade ago, ingested INF-α was reported to modify the onset of autoimmune diabetes in a commonly used animal model, the nonobese diabetic (NOD) mouse.
Lactulose was reported to modify systemic immune responses in a murine model; however, such findings were not confirmed by our immunoglobulin measurements.
This is possible because cdk5 was reported to modify the antiproliferative effect of PPARγ [75] and also because cdk5 was shown to be activated in adipocytes exposed to inflammatory signals.
Long-term EC was associated with ischemic heart disease mortality in the CTS [ 5] and was reported to modify short-term PM2.5 effects in one study [ 35], but not in others [ 33, 34].
Air pollution was not controlled in the study by Breton et al.[ 13], but was reported to modify the effect of a similarly functioning gene (GSS) on lung function growth in another study of this group [ 33].
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Therefore, many attempts were reported to modify the electrospun mats to gain more beneficial properties.
Soft (non-covalent and reversible) interactions between negatively charged NPs and proteins were reported to modify the tertiary structure of proteins and enzymatic activity in a size-dependent manner [42].
ISG15 has been reported to modify RIG-I and act as a negative feedback regulator [26].
mCD36ED were expressed in Hi-5 insect cells, which have been reported to modify recombinant glycoproteins by adding a core (α 1→3) fucose [24], [25].
Similarly, since Wolbachia has been reported to modify Drosophila's behavior [32], it is possible that Spiroplasma could improve the ability of its host to escape from wasp attacks.
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