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For example, beclin1, an evolutionarily conserved autophagy protein, was reported to interact with Bcl-2, and this interaction inhibits beclin1-dependent autophagy.
Recently, this Hsp70/Hsp90 protein folding complex was reported to interact with the CCT multi-subunit complex via an interaction with its β-subunit, CCT- β.
Notably, binding of unmethylated CpG sites by KFGG motif-containing CXXC domains does not exclude a role in protein-protein interaction as the CXXC domain of MLL1 was reported to interact with both DNA and Polycomb Repressive Complex 1 components HPC2/CBX4 and BMI-1 [50], [50].
When these interactions were compared to those between Arabidopsis orthologs, AtMKK9 was reported to interact with AtMPK10, 17 and -20 in Y2H [ 56].
In the adsorption study, the major Fe(III) species was reported to interact with As III) to form either inner-sphere monodentate or bidentate-binuclear complex.
eIF4E2 was reported to interact with 4E-T (Kubacka et al., 2013), which participates in translation repression and mRNA decay in TTP or microRNA mediated silencing (Kamenska et al., 2014; Kamenska et al., 2016; Nishimura et al., 2015).
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Secondly, to our knowledge none of the present top interactions have previously been reported to interact in risk for MDD.
Interestingly, many of them have been reported to interact with other viruses.
Respiratory chain complexes were reported to interact with each other to form supercomplexes, even megacomplex (Guo et al., 2017).
E3 SUMO-protein ligase PIAS has been reported to interact with and reduce the levels of claudin-2.
Several proteins related to the coagulation cascade, such as fibrinogen and fibrinogen degradation products, have been reported to interact with histones [31].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com