The protein Poly (rC -binding prC -bindingCBprotein reported to bind the RNCMPT00044 motif [ 60] and appears to be multifunctional [ 61, 62].
Furthermore, paclitaxel was reported to bind to microtubules strongly with an apparent binding constant of 0.87 μM, while SB-RA-2001 does not appear to bind to tubulin effectively.
Moreover, PC190723 was reported to bind to FtsZ at a site that was comparable to the paclitaxel binding site in tubulin, and like the tubulin polymerization enhancing activity of paclitaxel, PC190723 also enhances the assembly of FtsZ.
Previously, PHD1Lid was reported to bind with unmodified H3K4me0 (Li et al., 2010).
Recently, a small molecule (Abbott8) was reported to bind at the dimerization interface of survivin.
WHAMM was reported to bind microtubules and to be involved in ER to cis-Golgi transport [6].
[18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to bind mitochondrial complex-1 (MC-1).
18F-BMS was reported to bind tightly to cellular MC-1, which is the first component of the four electron transport complexes in the inner mitochondrial membrane [16].
Research groups started with the investigation of the 18F-labeled compound BF-227 that was reported to bind to both synthetic α-synuclein aggregates as well as β-amyloid fibrils in vitro (Fodero-Tavoletti et al. 2009).
Previously, Grk3 was reported to bind to CXCR4, but the sites were not further defined [44].
In response to cellular stress, αB crystallin was reported to bind actin microfilaments and aid in regulating actin dynamics in pinocytosis, thus preserving cell viability [25].
