To further improve the light scattering effect, a bi-layer structure was rationally designed (with this architecture as a scattering layer on top of a transparent, 12-μm-thick layer of nanocrystalline TiO2).
The structure of the compounds was rationally designed based on the available crystal structure coordinates of bacterial TPase.
Nilotinib, a second-generation oral TKI, was rationally designed based on the crystal structure of imatinib to be highly active against a wide range of imatinib-resistant BCR-ABL mutants and is approved for the treatment of newly diagnosed or imatinib-resistant or -intolerant CML, and has shown superiority over imatinib in first-line treatment for newly diagnosed CML.
By stabilizing the nucleating foldon, Im9 was rationally engineered to fold through a kinetic intermediate, while retaining the transition state structure of the homologous Im7 domain [ 48].
"I was rationally confident but emotionally terrified".
What was rationally and irrefutably real?
ABT-737 was rationally designed as an inhibitor of BCL-2, BCL-XL, and BCL-w through a nuclear magnetic resonance (NMR -based structure-activity relatioNMR -based) approach.
Guided by crystal structures of HIV-1 RT/DAPY complex and molecular modeling studies, a series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives were rationally designed via structure-based core refining approach, synthesized through the readily accessible synthetic methods and evaluated for their anti-HIV activities in MT-4 cells.
It is assumed that a frame structure protected with BRBs, termed as a dual structure, is rationally represented by a dual single-degree-of-freedom (SDOF) oscillator whose parts yield at different displacement levels.
These ideas may be either loosely related impressions approaching free association or more rationally structured sequences of thought and emotion.
