Initially, the GRP-R agonist AMBA [5] showed promising results for successful clinical use; however, its agonistic activity has caused acute gastrointestinal side effects such as nausea, abdominal pain, and emesis and its overall efficacy has been rather unsatisfactory in a phase I trial [6].
However, the assumption that the dielectric character of the membrane and of the protein are identical is rather unsatisfactory.
The proposed pathway is rather unsatisfactory because of the hydroxylation prior to cyclisation; the fact that 9 has not been observed; and lengthy reductive chemistry required to synthesise sorbicillin 10a.
The turnpike road was very steep and was deemed rather unsatisfactory:Why should coaches have to labour up the long hill from Newcastle to the top of Gateshead Fell, and then go down the steep descent to the Coach & Horses inn just before Birtley, while those coming from the south had to climb and descend the hills in reverse?
There was a rather unsatisfactory end to Sir Martin's legal action against WPP Italy country manager Marco Benatti, for libel and breach of privacy over a blog that compared the WPP chief executive to a mafia don, that saw him pull out of the trial two weeks in, accepting £120,000 in damages.
It is rather a flat, unsatisfactory ending.
AKI prevention and therapy has as of yet been rather unsuccessful and unsatisfactory.
There will be an amorphous cloud of points in genome space, and although some genomes will be slightly closer to one another than others, any attempt that we make to split the population into clusters will be rather ill-defined and unsatisfactory (as on the right of Figure 4).
The drilling of deep holes with small diameters remains an unsatisfactory technology, since its productivity is rather limited.
Receiving acupuncture seems to be rather an additional measure for individuals with multiple treatments and unsatisfactory outcomes than a judiciously selected treatment option.
