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The purified scFv was proven active and showed specific binding to HTNV GP antigen and then could be internalized into HTNV-infected cells.
The generality of this enzymatic mechanism for cleavage of recalcitrant polysaccharides was recently shown for a CBM33 member (CelS2) that was proven active on cellulose (Forsberg et al. 2011).
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Our recently designed A199S/F227A/S287G/A328 W/Y332G mutant of human BChE has a considerably improved catalytic efficiency against -cocaine and has been proven active in vivo.
Our more recently designed A199S/F227A/S287G/A328W/Y332G mutant of human BChE, denoted as cocaine hydrolase-3 (Cochas, has a considerably improved catalytic efficiency against cocaine and has been proven active in blocking cocaine-induced toxicity and physiological effects.
Until BPA is proven active at environmentally relevant concentrations (the low nanomolar range), it is not certain that it poses risks to human health.
Trehalose has been proved active against aggregation of polyQ-expanded huntingtin (43, 44), beta-amyloid (36, 42, 56), polyA-binding protein nuclear 1 (PABPN1) (45), the pathological prion protein (46), the amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD -associated protein TDP-43 (57), mutant synuclein (47) and also on the ARpolyQ (37).
Metallic nickel (Ni0) was proven to be the active species for the methane partial oxidation reaction.
The Syk-GFP construct was proven to remain functionally active in previous studies [15].
The TRiC sample was proven to be folding active under our freezing conditions by an actin refolding assay (Meyer et al, 2003).
It remains to be proven whether active targeting will be successful in clinical applications.
This is expected as the CMV promoter which drives the NTRK1 gene in the plasmid has been proven highly active in neurons [ 34].
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