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The similar but more disparate product distributions with compound 5 favor the conclusion that substrate modifications are primarily uncovering occult reactivities rather than markedly altering substrate-binding trajectories.
The VS approach was primarily employed to uncover potential MAT ligands of novel scaffold (i.e., those that are not clearly structure activity relatives of established MAT ligands).
The Resolution Foundation, a not-for-profit research organisation, said the problem it had uncovered was "primarily down to the failure of employers to pay staff at a level that adequately covers all of their working time".
"It was primarily about New York City".
Their audience was primarily white.
Hamilton was primarily a painter.
Calder was primarily a sculptor.
The move was primarily tactical.
This functional diversity is primarily achieved through sequence variation, and uncovering the sequence-function relationships for the kinase family is a major challenge.
"There's stuff being uncovered," McClure said.
DQAs are primarily an external audit process that focuses on uncovering hidden problems in collection, aggregation, and transmission of priority indicator data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com