The ESR2 repeat polymorphism (having two alleles of ≥25 CA repeats versus 24 CA repeats) was previously reported to be associated with increased risk of colon cancer among women, but not among men (OR women = 2.1 95% CI 1.2 - 3.6, OR men =1.0, 95% CI 0.6 - 1.6, p heterogeneity =0.03) [ 16].
The number of CCTTT repeats was previously reported to influence transcription of the NOS2 gene [ 47].
A comparable number of regions that are resistant to DNA demethylation and do not intersect with methylated IAP repeats was previously reported in mPGCs (Hackett et al., 2013; Seisenberger et al., 2012).
The first exon of TGFBR1 contains a polymorphic GCG repeat; (GCG 6 was previously reported as the tumor susceptibility allele associated with some types of cancer.
The 6.1-kb sequence is flanked on either side by copies of a 349-bp repeat that was previously reported to be associated with paired-end read conflicts, suggesting the coexistence of alternative genome structures (Sloan and Moran 2012b).
This result was somewhat surprising but does not preclude the possibility that mild folate depletion induced hypomethylation at satellite repeats, as was previously reported in colon cell lines in vitro [ 5].
Although the studied loci appeared relatively stable over several generations in vitro, a single repeat change was previously reported for fnVNTR-4 in F. noatunensis subsp. noatunensis GM2212 following successive culturing at 20°C [ 11].
The number of repeat A units was previously reported to correlate with the ability of Xist to induce silencing in differentiating mouse ES cells [ 14].
It had been previously reported that repeated injection of CpG-ODN protects mice from prion infections [50], suggesting beneficial effects of immune hyperactivity on prion susceptibility, but this treatment was subsequently found to disturb microarchitecture and functionality of lymphoid organs [51].
The method was previously evaluated with repeated measurements by two independent investigators and was found to have good reliability [ 24].
