Among five DNMT3A nonsynonymous variations detected in this study, R882H was predicted as a deleterious mutation by all three web-based prediction programs, as reported in the previous study [ 21] and another known variation (R736H) was also predicted as a deleterious mutation by two programs.
The secondary structure of the identified putative KLK homologous proteins was predicted as a consensus (i.e. 3 out of 5 predictions) of the combined output of CDM [95], Jpred3 [96], Porter [97], PSIPRED [98] and SSpro [99].
Therefore, an element [j, i] of the miRmR map matrix took the value 1 if the jth mRNA was predicted as a target of the ith miRNA by two or more target-prediction databases.
A miRNA-mRNA pair was connected with an edge if it concurrently satisfied two condition: (i) the miRNA exhibited a significant negative correlation with the mRNA across the samples in the comodule; and (ii) the mRNA was predicted as a target of the miRNA by at least one miRNA target prediction algorithm.
H2AFX transcription was predicted as a good target for hsa-miR-24-2 by all four prediction software types, and miR-24-2 was found to have two possible binding sites in the 3'UTR of H2AX mRNA (Table S1 in Additional file 1).
H2(1/4), molecular hydrogen in a fractional Rydberg state, was predicted as a further product.
Based on the biochemical composition and FT-IR analysis, the flocculant compound was predicted as a polysaccharide derivative.
A threshold phenomenon was predicted as a common feature characterizing dependence of the wearless-frictional resistance on the sliding velocity.
According to the bioinformatics analysis, junction adhesion molecule A (JAM-A, JAM-1, F11 receptor, CD321) was predicted as a potential target gene of miR-495.
Most notably, GPBAR1 which was predicted as a target for both 'tonifying and replenishing medicinal' and anti-cancer classes, suggest an influence of the compounds on metabolism [6].
A threshold phenomenon was predicted as a common feature characterizing dependence of the wearless frictional resistance on the sliding velocity vstroke.
