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The sample was predefined with one attribute in common as recipients of DH's 'HCAI Technology Innovation Award for outstanding contributions to fighting infections 2009'.
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Inclusion and exclusion criteria for study selection were predefined, with some selected specifically to minimise the risk of bias.
Answers were predefined with tick boxes or were described under 'other'other
Strength of discrimination was measured using the reassignment of supplemental individuals into the clusters that were predefined with the subset of 10 15 individuals from each sampling location, where higher percentage of correct reassignment indicates stronger discrimination (i.e. higher structure).
Heterogeneity was predefined as P <0.05 with the Mantel-Haenszel chi-square test or an I value >50%.
Familial predisposition was predefined as preeclamptic women with a first degree relative (mother, daughter or sister) also registered with preeclampsia in MBRN.
698 subjects, aged 50 90 were enrolled, and clinically acceptable tolerability was predefined based on experiences with PNEUMOVAX 23®, another vaccine routinely administered to this age group.
Substantial heterogeneity was predefined as P < 0.10 with I > 50%%.
The statistically significant heterogeneity was predefined as p < 0.10 with the M-H chi-square test.
Any obvious heterogeneity was predefined as P < 0.05 with the Mantel-Haenszel chi-square test or an I >50%.
Noninferiority was predefined as a 95% CI with a lower bound not exceeding −15%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com