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We found that a mannosyltransferase gene, ALG9 (Asparagine-Linked Glycosylation mutant 9; Disruptedsrupted In Bipolar Disorder 1), at chromosome 11q23 was physically disrupted by the translocation breakpoint [ 5].
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In a one-sided reaction involving the eyes, right-handed people tend to rub the right eye more than the left, making that side react more, said Dr. Marjorie L. Slankard, director of the allergy clinic at NewYork-Presbyterian. The many allergy cells around the eyes, called mast cells, can be physically disrupted so they release chemicals that cause swelling, redness and more itching.
As demonstrated in Fig. 1b the iv injection of unstable micellar drug-complexes will be physically disrupted during circulation causing rapid release of the free drug into plasma with no time to achieve EPR effect, which is a time-dependent process.
This suggests that many of the cells on the "wound" edge potentially lose their original morphology and function because they have been physically disrupted [ 15].
Briefly, approximately 100 mg of flash-frozen tissue were physically disrupted by placing the tissue in 1 mL of Qiazol lysis solution and sonicating in a heated (65 °C) ultrasonic water bath for 1 2 h.
The frozen samples were physically disrupted by impact and then transferred to 2 ml screw cap tubes containing 1 ml Tri-Reagent (Applied Biosystems) and a mixture of 2- and 4- mm acid washed glass beads.
The explanation for this phenomenon remains unclear even in the case of the BCR but it could be that phosphatases involved in attenuation of the signal have better access to Dectin-1 once the receptor is internalized or that the assembly or stability of signalling complexes is physically disrupted by receptor endocytosis 27– 30.
Spleens and mesenteric lymph nodes [9] were isolated and physically disrupted with the end of a syringe plunger, suspended in complete DMEM growth media and then centrifuged at 300×g.
"I was physically small.
He was physically active.
I was physically sick.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com