Until recently, the ε4 allele of the APOE gene was the only well established genetic risk factor for the typical late-onset form of the disease.
Until recently (Lommel et al., 2013; Vester-Christensen et al., 2013; Winterhalter et al., 2013), α-dystroglycan, a central component of the dystrophin-glycoprotein complex that serves to connect the cytoskeleton inside the cell with the extracellular matrix outside the cell, was the only well established O-mannoslyated mammalian protein (Barresi and Campbell, 2006; Endo and Manya, 2006).
The feasibility of performing indirect comparisons was assessed according to guidance from the Australian Pharmaceutical Benefits Advisory Board, because these are the only well established guidelines currently available [ 41].
She said: "CairnGorm is not only well established as one of the UK's premier snowsports centres, the funicular railway has helped make it a year-round attraction.
It is only when microscopy is well established as in the moderate transmission area that clinicians see a low proportion of positive cases and consequently this reduces the proportion of patients who are referred for diagnosis.
Stopping rules employing RR only are well established and optimal designs have been proposed in terms of minimizing the number of patients required for study [ 22].
Numerous studies evaluated the NO-related mediator orchestra and highlighted the friend-and-foe character of excess NO formation [ 2]: NO not only is well established as a reactive nitrogen species (RNS), often referred to as a 'final mediator' of sepsis-induced hypotension, but also acts as a scavenger of reactive oxygen species (ROS), such as the superoxide radical.
Savioke was only established last year.
The U.K. Space Agency was only established in 2010.
The government has demonstrated strong intent to tackle this problem; nevertheless, there are deficiencies in pollution monitoring systems, and there are only a few well established cancer registries in selected cities in China.
