These were centred on the concept of the Dolchstosslegende, or "stab in the back", in which the war was only lost because of liberal and socialist plotting against the brave troops at the front.
Interestingly, the expression of GFP driven by HCNR 81675 enhancer was only lost when RA signaling was abrogated at 5.5 hpf (Figure 3A G and 3O) but not at later stages such as 7.5 hpf or 9.5 hpf (Figure S1), indicating that the HCNR requires an early RA signal to be induced.
Cre expression only occurred in radial glial cells; hence, the second floxed allele was only lost in radial glial cells and their neuronal and glial descendents.
The two C-terminal and ancient introns, r and s, reveal the extremes of intron loss, with intron r being lost 10 times while intron s was only lost twice, in a mosquito lineage and in DwilGr64e.
Since the invasion and migration responses to TGFβ were lost in both Smad2 null and Smad3 null IMECs while the EMT response was only lost in the Smad3 null cells, we searched for a different underlying mechanism to explain the Smad dependency of the invasion response.
