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Simultaneously, thalidomide was omitted until the toxicity resolved to baseline or decreased to below grade 1.
The relevant agent was omitted, until the adverse events had resolved, followed by subsequent dose modification.
If musculoskeletal toxicities developed, treatment was omitted until the symptoms had abated.
If musculoskeletal toxicities were greater than or equal to National Cancer Institute – Common Toxicity Criteria (NCI CTC) grade 2 or other toxicity of grade 4 developed, marimastat was omitted until the symptoms had abated.
As the primary end point was feasibility, treatment was not to be delayed due to toxicity, rather the relevant agent was omitted until the adverse event had resolved, followed by subsequent dose modification.
If grade 2 non-haematological toxicity (except for alopecia) was observed, chemotherapy was omitted until resolution and then readministered at the next cycle at doses reduced by 25 50%.
Similar(52)
Exclusive rooting defines branches as derived and thus they are omitted until only the root is left, thereby establishing LUCA.
For the second and third round of analysis, all samples assigned to groups in the previous rounds were omitted until all samples had been clustered.
In case of persistent (⩾14 days) painful paresthesia or functional impairment, oxaliplatin had to be omitted until recovery and had to be restarted at 50% of the dose.
If toxicity of the severity described above recurred, then marimastat again would be omitted until the symptoms had abated and a further 50% dose reduction would be instituted i.e. alternate day dosing.
In the event that CTCAE Grade 3 QTc prolongation was observed (defined as an interval >500 msec or an increase of QTc of >60 msec from baseline with no medically significant symptoms), a confirmatory 12-lead electrocardiogram was required before LY2457546 doses were omitted until the QTc interval returned to <500 msec or below the 60 msec upper boundary.
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