Their studies show that the nuclear periphery is not refractory to gene transcription, but can modulate the activity of certain genes.
Importantly, this also indicated that CFP10-DCs were not refractory to additional stimulation.
When the membrane potential reaches threshold θ, and the cell is not refractory, it fires an action potential, gNa.
The authenticity of the PCR products was verified by sequence analysis confirming that the LplA1 locus in P. berghei is not refractory to recombination.
Moreover, they demonstrate that B. abortus infected macrophages are not refractory to further activation and also that such an activation does not lead to the elimination of replicating Brucella.
The P. berghei LplA1 gene locus is targetable by knock-in and also a gene replacement construct, clearly demonstrating that this gene locus is not refractory to recombination in P. berghei.
Thus contrary to initial indications from immuno-labeling studies [14], [23], β-catenin that remains unphosphorylated at S37 and T41 (ABC) is not refractory to cadherin-binding, but rather appears to be selectively targeted by cadherins.
In addition, those who were not refractory to taxanes had improved OS if treated with eribulin compared with control.
However, abundant heterochromatic H3K9me2 marks were found in locus 271, arguing that P35S is not refractory to heterochromatic histone modifications in tobacco.
These improvements in healthspan parameters suggest that pnc-1 mutants are not refractory to DR lifespan extension because they are simply sick.
INFAST was a Phase 3b, randomised, parallel-group, multisite, double-blind, placebo (PBO -controlled study of IFX in adults with moderate-to-severe, active axial SPBO -controlled refractory to Nstudy (Profocol P05336, NCT00844805).
