If it is not possible to practically realise values of the factors required by experimental designs, or if there is a constraint on the total number of experiments that can be done, then D-optimal designs can be very powerful.
"When we [Blumenthal went into business with his wife] bought the Fat Duck, we realised that it wasn't possible to recreate the noise of the crickets and the water, the crunch of the gravel and the smell of the lavender as it's just a tiny building on a main road, so the multi-sensory idea really began to take hold".
Nevertheless it is important to realise that it is not possible to internationally develop a standardized registration system, because the possibilities in each country are different.
Sensitive, clever men like Sajid Hussain might one day realise it is not possible to crack the codes of the elite while other forms of privileged education flourish, completely unaddressed.
"It was not possible for Mr Bakewell to realise there was a problem that day.
To avoid a collision, Reed said, he first thought about passing the Nissan on its left but, after realising this was not possible, tried to pass it on the right.
Le Monde reported that Forestier had admitted being part of a group formed to kill Mbaou, who was living in Val d'Oise, north of Paris, but told investigators after carrying out reconnaissance he realised the plot was "not possible".
He ran a bar-tobacconist here and only 15 days ago he helped me organise the opening of a village hall". French newspaper Le Monde reported that Mr Forestier had been heard admitting that he was part of a group formed to kill Gen Mbaou, who was in a town north of Paris, but told investigators that he later realised the plot was "not possible".
I have to realise it is not possible because there are so many associations who don't want to change.
When Skanska set out its ambition to be the most sustainable construction company in the world they quickly realised this would be not possible unless they took their supply chain with them.
But, tetrodotoxin is such a neat answer to the Juliet poison question that I was disappointed when I realised it just wasn't possible.
