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Dabney and Storey determined that the failure of the FDR algorithms was not methodological, rather the distributions of the null p-values corresponding to the most common choices for the Stage II analysis (e.g., t-test, permutation t-test, and Wilcoxon Rank Sum test) were non-uniform for the datasets which were considered.
Similar(59)
A successful pilot convinced Mr Schleicher that the problems were not methodological or operational but political.
While the variation was not distributed in a clearly bimodal fashion, the levels of methylation for each pair of CpGs showed a very high degree of correlation, suggesting this is not methodological (measurement error or sequence variants directly affecting probe binding).
Note, that the limitation is not methodological, but, rather, biological.
Reasons for selecting the GMTF study were not methodological.
Where a full paper was not available methodological quality was not assessed, as it was felt this would be a biased assessment without full data available Key: + yes; − no; ?
Significance values in that test of P < 0.001 or better can be taken as evidence that the consensus profile was not a methodological artefact and does represent a common pattern identified by observers.
In particular, the meta-analysis performed by the authors was not of high methodological quality.
The construction of two CDRs was not available for methodological analysis.
Because a scoping review is not intended to assess the quality of studies, emphasis was not placed on methodological rigor of the retained studies.
Secondly, expression data from the two cohorts were obtained using two different array platforms, indicating that the observed association was not subject to methodological bias.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com