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At each cellular division, telomeric DNA terminal regions are not fully replicated, which, if not counteracted by elongation by telomerase, can lead to telomere shortening.
However, in recent phase I/II trials and one unpublished phase III trial, these findings were not fully replicated.
These observations, demonstrating that the LmcDNA16 null parasites can undergo metacyclogenesis in vitro but not in vivo, suggest either that the metacyclic phenotype observed in the vector and required for parasite transmission in vivo is not fully replicated in vitro or that other factors are critical for differentiation in the sand fly.
Although we were not fully replicating their analyses and used a shorter time series and a sub-population of the UK, we do not believe this could explain the differences observed.
His moral compass was not fully formed.
But Kebede was not fully confident, either.
"Basically I was not fully concentrated.
Sadly, the project was not fully funded.
Each of the two measurements involves independent determination of the P450 concentration and the enzymatic activity via the standard curves shown in Additional file 2. The two measurements are not fully independent biological replicates, since they come from the same preparation of protein.
His effort wasn't fully rewarded.
This suggests that the lattices which contain these planes are not fully isotropic and therefore do not properly replicate the behavior of a real fluid in this particular situation, notably downstream from the expansion.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com