However, the deficiency in load balancing in DHTs arises when the overlay is not fully occupied or the namespace is not entirely covered.
When the transporter is not fully occupied by substrate, all rates of first-order reaction steps should be modified by a factor of [S]/([S] + K d).
Although the paper discusses load balancing, however, the experiment tested the scenario of having fully occupied network whereas the issue of load balancing is when the network is not fully occupied.
Quantitative HAADF STEM results show that the nominal Ge columns of the β′-Ge precipitates are not fully occupied by Ge, the intensity of these columns being consistent with an Al concentration of 30 ± 10%, or a vacancy concentration of 20 ± 10%.
I won't get into the other factors that affect happiness in my lifes, since I'm not fully occupied 24/7 trying to grow my food, and have too much time to think about stuff between episodes of "Louie" -- but food-wise, I couldn't be happier.
This indicates that most target sites are not fully occupied by the transcription factor, and hence that the concentration of the protein is limiting for binding, except perhaps for the strongest sites.
This is likely because the density is rather undefined, potentially because it is not fully occupied, a phenomenon commonly observed without externally supplied ligands and/or cofactors.
This implies that the protein is not already bound to nucleotide when purified (or at least is not fully occupied), but is then stabilized upon the addition of nucleotides.
It was assumed that overhead costs were low because, for example, no additional room had to be rented and available meeting rooms were not fully occupied with respect to time.
