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Similarly the study by Virta et al. investigated a manualised approach which was not formulation driven, although the topics of a few sessions were chosen by the participants.
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The generic formulation was not statistically bioequivalent to the brand formulations during steady state, although exposures were comparable.
Further studies confirmed that the nanoparticle formulation eliminated the need for premedication (since the toxic excipient Cremophor EL was not used in the formulation).
It was observed that formulation was not sensitive to the low temperature.
Addition of antioxidant preservatives to store the pharmaceutical formulation was not necessary.
Foam generated by this surfactant blend formulation was not considered as strong foam due to low concentration.
However, in these studies, the effect of temperature and Brownian motion was not considered in the formulation of the problem.
While the initial formulation was not wholly incorrect, it is possible there was an underestimation of the strength of Christopher's attachment to the collective.
The FDA withdrew US approval for the cough syrup Clistin Expectorant in 1982 after determining the formulation was "not … a rational combination" and lacked proven effectiveness.
Chronic administration of this parenteral formulation was not tolerable.
If the formulation was not available in the same quantity, the authors selected the closest quantity available.
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