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A recombinant glycoprotein D vaccine yielded a 38 42% efficacy in HSV1 seronegative women, yet was not efficacious at all in men and in HSV1 seropositive women (Stanberry et al., 2002).
In trial reports authors could report evidence that a treatment's efficacy was superior to placebo if 1 of 12 outcome measures showed a significant effect of treatment, whereas in another trial report in the same journal, authors could suggest that the same treatment was not efficacious if 2 or 3 of the outcomes showed significant efficacy over placebo.
In contrast to the EE enhancement by the equilibration after a short-term sonication applied to group 2, the equilibration after a long-term sonication applied to group 4 was not efficacious for the EE enhancement.
Use of this herd-specific multivalent vaccine designed to reduce metritis was not efficacious at reducing the risk of uterine disease or influencing production and reproduction in dairy cows.
Posterolateral visualization directly with the camera and via the anterolateral portal is efficient and associated with minimal morbidity but was not efficacious in the cohort evaluated.Level of Evidence:Level II.
Moreover, in those studies where probiotic supplementation was not efficacious against allergy [3], [4], [5], no probiotic-associated increases in IFN-γ were observed [3], [18], [27].
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Glucocorticosteroids are not efficacious.
Some commentators characterize Santayana as an epiphenomenalist, and there are some commonalities, specifically the view that spirit is not efficacious.
The treatment of migraine attacks with aura by triptans is difficult since triptans most probably are not efficacious when taken during the aura phase.
Sham surgeries are difficult to justify ethically, yet they have been successful in showing that accepted surgical procedures were not efficacious.
Medical therapy although useful in reducing the severity of other symptoms of endometriosis such as pain and menstrual disorders, is not efficacious to improve fertility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com