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Fatigue was common in all patients treated but was not dose limiting, and there was no evidence of coagulopathy.
The occurrence of metastases after RAD001 treatment was not dose dependent in the dose range tested, nor was it related to the duration of RAD001 treatment.
Survival was not dose dependent.
The magnitude of cytokine production was not dose dependent or dependent on the number of immunisations.
TNF-α production by THP-1 cells was not dose dependent to the amount of dCGN used.
Inhibition of S6RP phosphorylation was a highly sensitive marker of exposure to rapamycin, even in the lowest dose cohorts, such that its pharmacodynamic modulation was not dose dependent.
Similar(24)
However, the effect was not dose-dependent.
This effect, however, was not dose-related.
Transient uncomplicated hypophosphatemia was seen in seven patients and was not dose-related.
Biochemical assay revealed that groups with rhBMP-2 displayed an initial burst in cell growth that was not dose-dependent.
Results: Continuous administration of LPS increased the expression of each surfactant apoprotein mRNA, but the expression of mRNAs was not dose-dependent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com