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PRN 23, whose attitudinal behaviour was modified early in 2002 is an interesting case.
Based on the early data, the design of BIG 1-98 was modified early during the course of enrollment to allow for five additional pairwise comparisons, with analyses commencing at randomization [ 16].
The dimensions of the dental arch were modified earlier toward the values of the permanent dentition.
When QIBs become validated endpoints, this has important clinical implications as ineffective treatment can be modified earlier.
The findings from this study show that the non-transformed cell types and the ECM of the bone marrow are modified early in the development of leukemia, most likely via interactions that are mediated through direct cell contact and secreted cytokines, chemokines and other factors.
During apoptosis, eukaryotic initiation factors are modified early on, e.g. by dephosphorylation of 4E-BP1 and subsequent caspase-cleavage of eukaryotic eIF4G, both enforcing CAP-independent translation (26).
The legislation was modified earlier this year before it passed both chambers to address some of the concerns raised by the White House.
However, no specific analysis was performed in this study to explore whether the higher mortality for this group (RIFLE class F) was modified by earlier RRT initiation.
In general, the qPCR results showed that the expression of the analysed genes was modified very early during flooding, starting within 2 h (Fig. 5B).
The interactive chart on the FPbase website was modified from an earlier collaboration with K. Thorn.
The test in 2016 was modified from an earlier study (Leinonen et al. 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com