miR-1/miR-133 are mainly implicated in post lesion in mammals as well as in zebrafish14,17,22,23. Particularly, miR-133 has two isoforms, miR-133a and miR-133b, and their activity seems to be similar at the moment23.
Immediate early gene Arc expression was determined by immunohistochemistry to show if prefrontal cortices (PFC) and hippocampi were activated following RAM training as these regions are known to be mainly implicated in spatial memory.
In contrast, the under-abundant proteins were mainly implicated in transport, TCA cycle and respiration.
Stimulation of postsynaptic 5HT1A and 5HT2A receptors has been mainly implicated in the development of the syndrome.
It has been suggested that GlyT2 is mainly implicated in the control of inhibitory neurotransmission via GlyRs, whereas GlyT1 is considered to regulate the glycine level in both inhibitory neuron and excitatory neurons [4 8].
However, it has been suggested that Top2β is mainly implicated in the induction of DSB, while Top2α is essential for citotoxicity [30].
Thus far, the p24 proteins have been mainly implicated in the selection and packaging of secretory cargo proteins (cargo receptor model; reviewed in [2]).
However, the co-regulation of YER067W with metabolism-related genes and not heat-shock proteins, which are involved with protein homeostasis, suggests that YER067W is mainly implicated in energetic metabolism adjustments in response to adverse conditions.
The main finding of this paper strongly indicate that CD8+ T cells may have an additional role in TB as regulator of CD4+ T cell-mediated responses, which are mainly implicated in protection against MTB infection [3], [4].
