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Since all HSV-2-challenged animals were ultimately co-challenged with HSV-2 and SHIV-RT we were unable to accurately determine if HSV-2 shedding significantly decreased over time in macaques, although there was less reactivation upon biopsying at the later time points.
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Moreover, it was found that BDD deactivation was less pronounced and its reactivation was faster than that of the other electrodes.
In female mice, however, there was less of an effect on peak theta frequency following Mecp2 reactivation.
However, whereas the level of luciferase reactivation by Sp_Hsp104 was close to that of Sc_Hsp104 when overexpressed, Sp_Hsp104 was less efficient when expressed under the control of the Sc_HSP104 promoter on a centromeric plasmid.
However, gE-negative BoHV-1 is less effective in reactivation and reexcretion than wild type viruses in calves [ 4, 43].
Other reported mutagenesis studies suggest that the side chains of Phe295, Phe297, and Trp86 are less critical for the reactivation of iPrMP-mAChE by HI-6 [39]–[41] as substitutions of Phe295Leu, Phe297Ile, and Trp86Ala change the bimolecular rate constant by 0.9- to 1.4-fold [40].
This result might suggest that samples isolated after reactivation are less sensitive to meglumine antimoniate in vitro; however, the difference was not statistically significant.
We demonstrate clearly that in the absence of Ki-67 (therefore the absence of most or all of the perichromosomal compartment) NOR reactivation is less efficient during mitotic exit and subsequent ribosomal transcription is reduced.
The data suggest that although TGF-beta may effectively inhibit activation and recruitment of new T cells into the effector pool, it may be less effective in suppressing the reactivation of already polarized memory T cells that are less dependent on IL-12 and costimulation.
Strains with SIT 17, the most common pattern overall may be more actively transmitted and SIT 53 strains may be less virulent and associated with reactivation of past infections in older patients.
The disk harrow and the excavator may also lead to a reactivation, but they are less effective and therefore less recommendable.
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