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The amount of uPAR that was internalized in this first step was considered as 100% of the internalized receptor for quantification purposes.
Approx. 6.7 logCFU was found to be internalized in case of S. Typhimurium isolate and approx. 7.4 logCFU was internalized in case of S. Typhi isolate (Table 4).
While 53.3 % of the total cellular activity was found to be internalized for [68Ga]pentixafor, only 17.5%% of the total cellular activity was internalized in the case of [68Ga]NOTA-pentixafor.
To further reveal that the nanovehicle was internalized in HeLa cells rather than being bound to the cell surface, bio-TEM was used to analyze the nanovehicle-treated cells.
These results demonstrate that the nanogel was internalized in cancer cells by folate receptor-mediated endocytosis and was then disintegrated by various enzymes in the lysosome, leading to restoration of photoactivity.
Doxorubicin-loaded HFn acts as a "Trojan Horse": HFn was internalized in cancer cells faster and more efficiently compared to free doxorubicin, then promptly translocated into the nucleus following the DNA damage caused by the partial release in the cytoplasm of encapsulated doxorubicin.
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Hence, the most dramatic inhibition of EGFR internalization occurred at 2 min with 60% being internalized in control cells compared with 20% being internalized in cells expressing Tom1L1/Y460F, Tom1L1/Y392F or Tom1L1/Y460F SH3.
PGA-Dox nanocapsules were internalized in large numbers by LIM1215 colorectal tumor cells, with most of the internalized capsules being taken up by the lysosomes.
We found that CysLT1 is internalized in a clathrin/Rab-5-dependent pathway; we also suggest that this internalization is arrestin-3-dependent.
So multiplication is a double terror: not only is it remote from our intuitive sense of number; it has to be internalized in a form that clashes with the evolved organization of our memory.
The secular idea, the state system and the balance of power, pop culture jumping tariff walls and barriers, the state as an instrument of welfare, all these have been internalized in the remotest places.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com