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The effect of anti-CTLA-4 antibodies on solid tumours was initially recognised in mice in the late 1990s.
Genomic instability or microsatellite instability (MI) in simple repeated sequences was initially recognised in colonic carcinomas and subsequently in other tumours.
It was initially recognised from histological examination of cattle brains submitted as part of the UK statutory reporting of BSE suspects [ 6].
In contrast to the reassurance provided by normal fetal activity, reduced fetal movements (RFM) can be an important symptom preceding fetal death; this was initially recognised in cohorts of women completing fetal movement charts [ 2].
The EPLINα isoform has been implicated in the progression of various cancers, and this was initially recognised in oral cancer, breast, prostate and xenograft tumours where EPLIN expression was either downregulated or completely abolished [ 4].
Rottweiler leukoencephalomyelopathy (LEM) was initially recognised in the US as a cause of chronic progressive ataxia with insidious onset in Rottweilers between 1.5 and 4 years of age [ 1].
Similar(52)
37 subspecies of the waterbuck had been initially recognised on the basis of coat colour.
Apparently homogeneous stem cell populations may be found to contain discrete subsets of cells that could not be initially recognised because of the absence of suitable markers.
Putative MSNs were initially recognised by their low basal firing rates of 0.1 1 Hz during SWA.
NES-positive cells were initially recognised as multipotential stem cells in the adult pancreas [ 26].
This is in contrast with medical specialties where professions allied to medicine may not lead the team and their role may not be initially recognised or supported".
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