Taken together with the endocytosis studies above, our data suggest that NP1 is initially internalized by caveolae followed by delivery to the endosome.
Our data revealed that NP1 and NP1-PEG are initially internalized by caveolae-mediated endocytosis, which triggers the stimulation of an ERK1/2 signaling pathway necessary for the processing of LC3β-I to LC3β-II and stimulating autophagosome assembly.
After injection into the skin, promastigotes are initially internalized by neutrophils before being phagocytosed by macrophages and delivered to the mature phagolysosome compartment where they differentiate to the small, round, aflagellate amastigote stage.
This was initially controversial.
Litton was initially evasive.
Zaremba was initially skeptical.
Tem8 was initially identified as a gene up-regulated in tumors, and is one of two anthrax toxin receptors, the other being capillary morphogenesis gene 2 (CMG2)/ANTXR2 which together recognize and internalize anthrax toxins [35], [36], [37].
The initial washout kinetics of radioactivity from these EGFR-positive cell lines was rapid; however, approximately 30% of initially internalized radioactivity was retained inside the cells at 24 h (Figure 2c,d).
Clare's still internalizing whatever is to be internalized.
The coat, which is initially assembled on flat membrane, starts internalizing and reorganizing when actin polymerization begins.
