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CBP/p300 was initially implicated the transcriptional activation imposed by phosphorylated CREB [41].
The phagocyte NADPH oxidase NOX2 was initially implicated in innate immunity and inflammation.
The upstream region was initially implicated in rheumatoid arthritis (RA) susceptibility in the Wellcome Trust Case Control Consortium study [ 2], and was subsequently replicated in large European and American populations [ 3, 4].
Defective autophagy was initially implicated in neurodegenerative disease because increased levels of autophagic vacuoles were observed in AD, HD and PD patient brain tissues as well as in animal models of each disease (reviewed in [71]).
Chlamydial protease, or proteasome-like activity factor (CPAF), which is a potent and promiscuous cysteine protease capable of cleaving many host proteins, was initially implicated in this degradation [ 27].
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Three of the company's growers were initially implicated in the outbreak.
Both ZNF224 and PCK1 were initially implicated by AD GWA studies; however, neither locus has yet been consistently replicated in subsequent genetic studies, and little is known about their potential mechanism of action in disease pathogenesis.
Residues 126, 129 and 155 were initially implicated in the binding of AVFluIgG03 since differences at these positions were identified between the 2005 clade 2.3 and1/05 and the clade 0 and clade 1 viruses which failed to react with the AVFluIgG03 by MN and HI tests (Table 2 4).
12 PIs were initially implicated as the primary cause of the observed changes.
They were initially implicated in feeding behavior and sleep\wake cycles (de Lecea et al., 1998; Sakurai et al., 1998).
In particular, CD4+ Th cells producing IL-17 and IL-22, named Th17, have been initially implicated in the pathogenesis of many chronic inflammatory disorders instead of Th1 cells.
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