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Complement was initially discovered as an assembly of plasma proteins "complementing" the cytolytic activity of antibodies.
CRISPR was initially discovered as the adaptive immune system of bacteria and archaea (Wiedenheft et al., 2012).
As a member of ubiquitin-specific protease family, USP33 was initially discovered as a substrate protein binding to VHL E3 ligase (Li et al., 2002).
The substance was initially discovered as a component of endogenous monoamine oxidase (MAO) inhibitory activity, tribulin, and subsequently identified as a selective inhibitor of MAO B [12].
A3G was initially discovered as potent anti-HIV1 factor countered by the HIV vif gene product [9].
DJ1 protein was initially discovered as a putative oncogene that promotes cell survival by negatively regulating tumor suppressor PTEN [41].
Similar(21)
Although they were initially discovered as DNA polymerase processivity factors, sliding clamps are used by many enzymes required for DNA replication and repair.
We note, that heat shock proteins were initially discovered as participants in the cellular response to stress.
Rck1 and Rck2 in the budding yeast were initially discovered as suppressors of fission yeast checkpoint mutation (radiation and hydroxyurea sensitivity) [24].
Transposable elements were initially discovered as important factors in the regulation of gene expression in maize, and termed controlling units [44].
Two proteins that were initially discovered as being highly expressed in the appressoria of M. grisea and essential for pathogenicity (Mas1 and Mas3) [53] also have homologues in a number of species of filamentous fungi (Table 5).
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