The existence of breast cancer-initiating cells was initially demonstrated by Al-Hajj and colleagues [ 1] using antigen expression, and subsequent studies have employed several methodologies to identify and isolate these cells.
The successful application of the estimated noise power for speech enhancement was initially demonstrated in [41, 42] with hearing aid application.
This was initially demonstrated for influenza viruses by a simple membrane fusion assay, hemolysis of erythrocytes that occurs only if virus particles containing cleaved HA or HEF are exposed to acidic pH (Formanowski et al., 1990; Huang et al., 1981; Kitame et al., 1982; Lenard and Miller, 1981; Maeda and Ohnishi, 1980; Ohuchi et al., 1982).
The well-known SK growth mode for the self-assembly of semiconductor crystals was initially demonstrated on III-V and II-VI families of semiconductor materials [12, 13]. Figure 1 Selective pre-pattern free self-assembled Ge nano-dots were locally formatted by laser annealing technique.
On the contrary, E. coli grew normally on the TOChN-F as well as on the other area in medium C. It was initially demonstrated that the DEChN-F and DE-TO-ChN-F can inhibit the growth of E. coli to a certain degree.
This was initially demonstrated in experimental animal models [20].
Genetic susceptibility to VL was initially demonstrated in mice [5].
The interaction of FMRP with trimethylated lysine residues was initially demonstrated via NMR titration, but not in the context of histone-derived peptides[22].
enzb431 was initially demonstrated to be linked to SSLP markers near the centromere of chromosome 7 based on the MGH mapping panel (http://zebrafish.mgh.harvard.edu/zebrafish/index.htm).htm
The importance of Wnt signalling in the control of bone mass was initially demonstrated by the high and low bone mass phenotype caused by loss- and gain-of-function LRP5 mutations, respectively [16].
The potential therapeutic effect of AOs was initially demonstrated in dystrophic mdx muscle cells that harbor a nonsense point mutation in the exon 23, resulting in the lack of dystrophin expression [1].
