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Age was initially analysed as a continuous covariate.
Each archipelago was initially analysed independently, after which general patterns were then compared among islands.
The data was initially analysed by frequency counts, means, medians and T-tests.
In our approach, the population was initially analysed as a whole (i.e. all patients fulfilling our inclusion criteria).
Internal consistency was initially analysed in the Medikinet® retard observational study (study 2) and the OBSEER (study 3) samples separately.
The significance of the variances of means of indices in multiple treatment groups was initially analysed by ANOVA.
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The results were initially analysed by the Oliver and Pharr method.
The data were initially analysed for sphericity using the Mauchly's test of sphericity.
Data were initially analysed using Student's t-tests, followed by Mann-Whitney U tests and Kruskall-Wallis tests.
The two studies were initially analysed separately, but as the results were very similar, for this paper they have been analysed as a whole and broken down by gender, nationality and age rather than by cohort.
All SNPs were initially analysed using allelic and genotypic χ2 tests (Table S 1).
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