The IC50 for the inhibition indicates that one molecule of ZOL was inhibiting more than one molecule of the mutant FPPS.
One possibility, therefore, was that Hdac1 was inhibiting the Notch pathway and thus decreasing the Notch-mediated inhibition of ascl1b via Her genes, which are the major effectors of Notch signalling in zebrafish (Cunliffe, 2004; Louvi and Artavanis-Tsakonas, 2006).
Or maybe our presence was inhibiting them.
On Aug. 11, their social worker from Selfhelp, Fran Tarshish, realized that the stifling heat in their apartment was inhibiting Mrs. Abramov's ability to breathe.
But he suggested the threat of extradition hanging over him was inhibiting his recovery and it might be in his interests to go to South Africa.
But funding statistics lent credence to this view and made it clear that chronic underfinancing was inhibiting a full recovery in the city.
Yesterday Eady accepted concerns raised by Guardian editor Alan Rusbridger that uncertainty surrounding the law on libel was inhibiting responsible reporting.
It may be instead that the particular type of expression associated with Michelangelo, of an almost cosmic grandeur, was inhibiting.
He privately expressed that their round-table transfer policy was inhibiting, despite public attempts at a united front.
The agency had too much autonomy, they argued, and was part of a regulatory system that was discouraging banks from lending money, which in turn was inhibiting economic growth.
Gerwig and Baumbach collaborated on the script of their prior film together, "Frances Ha," but there the protagonist more clearly mapped onto Gerwig's own artistic ambitions, and the personal connection was inhibiting.
