It was indicated down-regulation of NDRG2 resulted in poor cell viability.
It was indicated that down-regulation of RhoA activity by transfection of HMVECs with RhoA N19 abolished the increase of HMVEC monolayer permeability induced by AGE-HSA treatment.
This was indicated by down-regulation (3-fold on average) of CCR-mediated components: alternative (to glucose) substrate transport and utilization systems like galactose (MglAB), maltose (MalBEFKM), galactitol (GatABC), L-arabinose (AraF), D-ribose (RbsAB), C4-dicarboxylates (DctA) and acetate (ActP, YjcH).
It is possible that SBK may at some point struggle to progress through the G2/M phase, which may be indicated by down-regulation of Ccnb1 and Cdc2a, whose products are essential in later cell cycle stages.
Fluconazole is an obvious choice for susceptible species, while voriconazole can be indicated as step-down therapy for C. krusei or voriconazole-susceptible C. glabrata.
In the current study, perturbations in the energy metabolism of old muscle were indicated by the down-regulation of five isoforms of monomeric creatine kinase (CKM) (LIS-spots 1261, 1266, 1276, 1289 and 3617).
The direction of the changes under these different treatments is indicated by up and down for induction or repression, respectively.
GA-responsive proteins are indicated as follows: LD, down-regulated protein; LU, up-regulated protein.
Up- and down-regulation is indicated by positive and negative values, respectively.
Transcripts significantly up- and down-regulated are indicated in blue or red, respectively.
Transcripts significantly up- or down-regulated are indicated in blue or red, respectively.
