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Thus, the absence of XAD in S. cerevisiae strain TMB4531 could indicate that the protein folding of this halophilic protein was indeed problematic, and the increased d-xylose bioconversion rate observed in this strain in comparison to TMB4530 was probably caused by an increased metabolic burden in TMB4530 expressing and assembling the Fe S cluster-containing XylD.
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Those ferocious crowd scenes are indeed problematic.
Sexual-harassment law is indeed problematic.
JB Quotas are indeed problematic but there are other possible affirmative action interventions, such as requiring departments, conferences and journals to monitor closely the number of women applying or submitting papers compared to those accepted.
It is indeed problematic that more English trained players are not fed back into the English game at a later date, but expecting them to stay at their hometown club is – just maybe – too much to ask in the modern game, irrespective of how well they are coached.
While the paucity of validation quality data and robust verification, validation, and accreditation approaches are indeed problematic, that topic is beyond the scope of this paper.
The unjustified proliferation of new rights is indeed problematic because it spreads skepticism about all human rights, as if they were merely wishful thinking or purely rhetorical claims.
This is indeed problematic because intuitions can be highly misleading and relevant logical impossibilities fairly ungrounded if they cannot be supplemented by relevant theoretical impossibilities based on current science in order to avoid the jump into futile fantasy.
Suu Kyi's comments are indeed problematic.
While I don't necessarily disagree with the plaintiffs' position -- these laws are indeed problematic and should be amended - -I vehemently oppose their tactics.
It is indeed problematic that antibodies deemed specific for NB should actually be detecting serum proteins not only of the same species but also across species.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com