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Further, it was shown that mutagenesis of the three cysteines that comprise the radical SAM motif yields inactive enzyme, which was incompetent for reductive cleavage of SAM.
The alcohols were dehydrated to provide an isomerically homogeneous population of a tetraene intermediate for facile analysis; this intermediate, however, was incompetent for subsequent thiolation due to the intransigence of the tryptophan-derived enamides toward protonation.
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Liberal democrat councillors in Cornwall have accused the Tory-led authority of being "incompetent" for not being fully prepared for the switch over to the new system.
Most significantly, CP subunits dissociated from polymorphic virions are incompetent for in vitro reassembly.
Indeed, many birds of the latter orders were found to be incompetent for transmission.
Furthermore, H3K27me3 is well recruited to the Xi by the Xist A-repeat mutant described as being incompetent for gene silencing (Kohlmaier et al. 2004).
Domestic as well as wild ungulates exert a powerful zooprophylactic effect on Lyme disease spirochetes because they are incompetent for these pathogens.
In line, the binding to liposomes of the two deletion mutants, which are incompetent for import into cyanelles [ 8], was insignificantly enhanced when using proteoliposomes (Fig 6D, E), because the increase was in the error range of the experiment.
We next explored the effect of proteasome inhibition on the nontranscriptional oscillator in cells that were incompetent for de novo TTFL component synthesis, i.e., Ostreococcus cells in constant darkness.
In fact, the over-expression of FAPP1-PH in cells, though stimulating tubule formation at the TGN, inhibits cargo transport [8], as the FAPP1-PH-induced tubules are incompetent for fission and for fusion with the plasma membrane [8].
Investigators have concluded that roe deer (Capreolus capreolus) [ 6] and red deer (Cervus elaphus) [ 7- 9] are incompetent reservoirs for B. burgdorferi.
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