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Interestingly, the βNAC subunit was implicated as having apoptosis-suppressing activity at the mitochondria in Caenorhabditis elegans.
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Detoxification of cisplatin includes gluthione conjugation, and glutathione S-transferase (GSTπ) has been implicated, as have two members of the multidrug resistance related protein family, MRP1 and MRP3, which are required to transport conjugated xenobiotics [ 21].
Bone morphogenetic protein-7 (BMP-7, OP-1) is a secreted growth factor that is predominantly known for its osteoinductive properties, though it has also been implicated as having a role in mammalian kidney development.
Triclosan has been implicated as having a hormone-altering effect in animal studies.
NIP45 is implicated as having a function in gene regulation [27].
Alternatively, the KCNK two-pore potassium channels identified as being central to eliciting tingle [11] have also been implicated as having a role in anesthesia [11], [42].
Both SPT4 and SPT5 are required for efficient transcription elongation and have been implicated as having roles in coupling transcription and splicing [55].
Meg3/Gtl2 is the founding member of a much larger imprinted gene region that has been implicated as having parent of origin effects in three mammalian species.
Integrins are a family of cell adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions [1], [2], [3] that also have been implicated as having a role in contributing to mammalian sperm-egg interactions.
Numerous proteins have been implicated as having a crucial role in metastatic cancers.
Bile and acid have previously been implicated as having a role in the mechanism of upper GI cancer.
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