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Determining the optimal cut-off of the gene rank was, however, challenging because it was not possible to estimate the number of virulence genes in a genome in advance.
Electron microscopy was, however, challenging in this mixed culture system and clearly identifiable neurite/fibroblast interfaces were rare.
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The implementation of this strategy is, however, challenging.
Current developments are however challenging the progressive realization of human rights worldwide.
It is, however, challenging to keep a comprehensive dictionary that contains all the entities of interest.
Experiments at reservoir conditions (high temperature, high pressure, and live oil composition) are, however, challenging.
Updating is, however, challenging when the new compounds are far outside of the original calibration domain space.
Direct quantitative detection of the relaxation behaviors of thin polymer films at nanometer scale by traditional instruments is however challenging.
This is however challenging as current controller designs for battery charging have no mechanisms to incorporate such information.
Circulation of the broth between the bioreactor and the membrane unit can be however challenging from physiological points-of-view.
It is, however, challenging to do it with a barrel of oil around twenty five dollars.
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