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The resistance phenotype was transmitted as a maternal, cytoplasmic factor and was fully reverted in flies cured of Wolbachia.
We found that RIG-I or MDA5 mutants with low ATP hydrolysis activity exhibit constitutive activity but this was fully reverted when associated with mutations preventing RNA binding to the helicase domain.
As shown in Fig. 4A, induction of DNA synthesis in response to 10 nM PGE2 in HT-29 cells was fully reverted by the administration of the cAMP raising agonist isoproterenol or pertussis toxin (PTX), a specific inhibitor of heterotrimeric Gi-proteins.
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These effects were fully reverted in the presence of IFN-γ.
In summary, mPIN lesions in young MPAKT mice were fully reverted upon RAD001-treatment; however, mPIN lesions in Hi-MYC and MPAKT/Hi-MYC bigenic mice did not respond to RAD001 despite effective mTORC1 inhibition.
For new columns, regeneration by TFA treatment had a drastic effect on column performance that could not be fully reverted even by very long reduction and rinsing periods.
Importantly, the neurite impairments were fully reverted by lentiviral overexpression of single spastin isoforms (M1 or M87), revealing for the first time that SPG4-related pathological phenotypes can be abrogated in patients' cells.
Further proving this redundancy, CHX-induced sensitisation (which was associated with reduced expression of cFLIP, Bcl-2 and Bcl-XL) could be fully reverted by overexpressing only one anti-apoptotic factor (Bcl-XL).
Compound 9 (1 mg/kg, ip) was fully efficacious in reverting scopolamine-induced amnesia in mice.
After the third cycle of transformation, reverted austenite was fully stabilized.
Hence, reverted austenite was fully stable and the next quenching in liquid nitrogen yielded full suppression of γ-α transformation resulted from the dimensional effect.
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