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Later on, we found that synthesis of 2-isomer of 5,8-O-dimethyl ether of shikonin was accessible through the direct methylation of shikonin [9], while its corresponding 6-isomer was formidable to be prepared.
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They are formidable, to be sure, but they entail hikes, not climbs.
"That would be a mistake to make because all the 32 teams in the pot were worth their places and would be formidable to tackle in the finals.
However, due to the bottleneck of computational limitations, it is formidable to use such expensive potentials to deal with the energetics and geometries of these clusters with respect to a large number of water molecules.
The technical challenges involved in pulling off dual roles were formidable to say the least, particularly given the film's relatively lean budget of around $25 million.
It is formidable to identify very low abundant glycopeptides in a complex sample.
Elsewhere Sol Campbell was formidable enough to let John Terry gradually reacquaint himself with the contest after injury.
The richer developing countries, such as Brazil or India, where the state apparatus was formidable, were reluctant to cede ground to outsiders.
There appear to be formidable obstacles to extending the system to cover the whole university, including compatibility of equipment and the reliability of the network infrastructure.
The palace was formidable, with walls strong enough to withstand artillery fire.
Despite these biological possibilities, there are formidable obstacles to life on Titan, and any analogy to Earth is inexact.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com