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Finally, the commitment of staff to the organisation – an important element in implementation process – was felt to include an implicit modicum of cynicism or lack of conviction about the extent and nature of organisational support to see through the changes required.
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Patients in whom chemotherapy was thought to be of uncertain indication and who might, therefore, benefit from molecular diagnostics were felt to include selected patients with node-negative disease, those with one to three positive nodes, and patients aged <35.
Additional acute toxicities that were felt to be treatment-related included radiation-induced xerostomia and one case of hypothyroidism in a patient who experienced nausea and emesis after receiving the thyroid blocking agent prior to treatment.
In terms of children's consumption of sugary foods and drinks, also many extra-familial factors were felt to be of influence, including the school, the social environment, commercials and television, supermarkets and affordability of foods.
In addition, 82% had two or more pathological processes that were felt to contribute to dementia, including 35% with cerebrovascular disease and 26% with Lewy body disease.
Examples that are felt to be the result of autoimmunity include rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), psoriasis, systemic sclerosis (SSc), and Sjogren's syndrome (SS).
Following a full review of the remaining articles, 32 articles were felt to contain relevant information and were included in the review.
As some of the tumours overlapped the junction between oral cavity and oropharynx sites (in particular tonsillar pillar and soft palate), it was felt appropriate to include HPV status to clarify the underlying molecular aetiology.
In all, 100 patients were recruited in phase 1 and 2 (as with modification to the guidelines, it was felt appropriate to include a large number of patients at this stage) and 50 patients in phase 3.
As such it was felt appropriate to include this exemption in the scenarios, even though it is applied as a constant annual input across the whole UK fleet4 As it seemed that this exemption makes more of an impact on BEV than PHEV, scenarios were tested where only BEV benefited from the exemption.
Thus, it was felt essential to include these interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com